Islamic Calendar

Saturday, September 18, 2010

Semiconservative model on new and old synthesize histone


The inheritance and maintenance new and old synthesize of DNA b can be explain by semiconservative model.  But how is the inheritance of epigenetic traits—modifications of chromatin proteins (histones) and DNA that do not alterthe sequence—affected by dynamic changes in chromatin organization during eukaryotic cell division?

Recently study (Xu et al.) explore how parental (old) and newly synthesized histones associate after replication. The basic unit of chromatin, the nucleosome, has a core particle of eight histones—two pairs of histone H3-H4 as a tetramer flanked by two dimers of histone H2A-H2B. Histones can be present in distinct forms or variants, and they may harbor specific posttranslational modifications that can define a given epigenome ( 1, 3). How do these particular markings sustain passage through replication? An attractive hypothesis has been a semiconservative mechanism in which parental histones are combined with newly synthesized histones within the same core nucleosome. The presence of parental information as a template to reproduce the same marks on new histones provides a convenient means to ensure accurate reproduction of the initial marking at the same place. But can parental and new histones mix?

Histones H2A-H2B readily exchange as dimers, but H3-H4 tetramers are thought not to split. However, newly synthesized H3 and H4 can exist as dimers when associated with histone chaperones. By their study that have 3 possibility of model of the Histone inheritance. First with H3-H4 only new tetramer,  second with mixed H3-H4 tetramer and third with only old tetramer.

Future work will investigate how the choice between histone splitting and nonsplitting is made within a cell and
whether this is regulated during cellular life or during development.


Naked for our brain???? (what make us human 1.8)

Did you notice that among mammal we are the fur-less. What are significantly this characteristic in human evolution. Recently studies, The evolution of hairlessness helped to set the stage for the emergence of large brains and symbolic thought.

Among primates, humans are unique in having nearly naked skin. Every other member of our extended family has a dense covering of fur—from the short, black pelage of the howler monkey to the flowing copper coat of the orangutan—as do most other mammals. Yes, we humans have hair on our heads and elsewhere, but compared with our relatives, even the hairiest person is basically bare.

Before explain further, lets discuss what important of hairy body to mammal and how human adaption differ from another animal.Hair provides insulation and protection against abrasion, moisture, damaging rays of sunlight, and potentially harmful parasites and microbes. It also works as camouflage to confuse predators, and its distinctive patterns allow members of the same species to recognize one another. Furthermore, mammals can use their fur in social displays to indicate aggression or agitation: when a dog “raises its hackles” by involuntarily elevating the hairs on its neck and back, it is sending a clear signal to challengers to stay away.


Another mammal that hairless because of  evolutionary adaptation. Such as the naked mole rat, hairlessness evolved as a response to living in large underground colonies, where the benefits of hair are superfluous because the animals cannot see one another in the dark and because their social structure is such that they simply huddle together for warmth. In marine mammals that never venture ashore, such as whales, naked skin facilitates long-distance swimming and diving by reducing drag on the skin’s surface.


Human hairlessness is not an evolutionary adaptation to living underground or in the water— the popular embrace of the so-called aquatic ape hypothesis notwithstanding.


Keeping cool is a big problem for many mammals, not just the giant ones, especially when they live in hot places and generate abundant heat from prolonged walking or running. These animals must carefully regulate their core body temperature because their tissues and organs, specifically the brain, can become damaged by overheating.


Mammals employ a variety of tactics to avoid burning up: dogs pant, many cat species are most active during the cooler evening hours, and many antelopes can off-load heat from the blood in their arteries to blood in small veins that has been cooled by breathing through the nose. But for primates, including humans, sweating is the primary strategy. Sweating cools the body through the production of liquid on the skin’s surface that then evaporates, drawing heat energy away from the skin in the process. This whole body cooling mechanism operates according to the same principle as an evaporative cooler (also known as a swamp cooler), and it is highly effective in preventing the dangerous overheating  of the brain, as well as of other body parts.


Not all sweat is the same, however. Mammalian skin contains three types of glands—sebaceous, apocrine and eccrine—that together produce sweat. In most species, sebaceous and apocrine glands are the dominant sweat glands and are located near the base of hair follicles. Their secretions combine to coat hairs with an oily, sometimes foamy, mixture (think of the lather a racehorse generates when it runs). This type of sweat helps to cool the animal. But its ability to dissipate heat is limited. G. Edgar Folk, Jr., of the University of Iowa and his colleagues showed nearly two decades ago that the effectiveness of cooling diminishes as an animal’s coat becomes wet and matted with this thick, oily sweat. The loss of efficiency arises because evaporation occurs at the surface of the fur, not at the surface of the skin itself, thus impeding the transfer of heat. Under conditions of duress, heat transfer is inefficient, requiring that the animal drink large amounts of water, which may not be readily available. Fur-covered mammals forced to exercise energetically or for prolonged periods in the heat of day will collapse from heat exhaustion.


The human not sweat like other primates. Humans, in addition to lacking fur, possess an extraordinary number of eccrine glands—between two million and five million—that can produce up to 12 liters of thin, watery sweat a day. Eccrine glands do not cluster near hair follicles; instead they reside relatively close to the surface of the skin and discharge sweat through tiny pores. This combination of naked skin and watery sweat that sits directly atop it rather than collecting in the fur allows humans to eliminate excess heat very efficiently.


What are significant of the different adaption of human for heat regulation in the body The loss of most of our body hair and the gain of the ability to dissipate excess body heat through eccrine sweating helped to make possible the dramatic enlargement of our most temperature-sensitive organ, the brain. Whereas the australopithecines had a brain that was, on average, 400 cubic centimeters— roughly the size of a chimp’s brain—H.ergaster had a brain twice that large. And within a million years the human brain swelled another 400 cubic centimeters, reaching its modern size. No doubt other factors influenced the expansion of our gray matter—the adoption of a sufficiently caloric diet to fuel this energetically demanding tissue, for example. But shedding our body hair was surely a critical step in becoming brainy.

Again the naked adaptation of human just for increase brain ability, perhaps the explanation about the evolution of minds. Perhaps some evidence.

Ancient Siberian finger leads to new possible human lineage



The scientist has found that the DNA from ancient Siberian finger did not match any of modern human DNA or a Neadratal.  To be more specific this is the mitochondrial DNA (mtDNA). When ancient-DNA expert Svante Pääbo gave his colleague Johannes Krause a sample of a 40,000-year-old human finger bone from a Siberian cave, he had only one question: Was its mitochondrial DNA (mtDNA) that of
a Neandertal or a modern human?
It was neither. Evolutionary geneticists Pääbo and Krause, of the Max Planck Institutefor Evolutionary Anthropology in Leipzig, Germany, have apparently identified a new lineage of ancient human, the first time that this has been done using ancient DNA and not fossil bones.

“I couldn’t believe it,” Pääbo says. “I thought Johannes was pulling my leg.” The
complete sequence of mtDNA from the finger bone, reported online this week in Nature, suggests that Central Asia was occupied at that time not only by Neandertals and Homo sapiens but also by a third, previously
unknown hominin lineage. “This is the most exciting discovery to come from the ancient DNA field so far,” says Chris Tyler-Smith, a geneticist at the Sanger Institute in Hinxton, United Kingdom. “A stunning piece of
work,” says Terence Brown of the University of Manchester in the U.K.

The work complicates the human story, much as the discovery of the controversial H. floresiensis—a.k.a. the hobbit—has upset earlier and simpler views of early human migrations around the globe. If four hominins including the hobbit were alive about 40,000 years ago, “the amount of human biodiversity … was pretty remarkable,” says geneticist Sarah Tishkoff of the University of Pennsylvania. For now, Pääbo’s
team is not naming the new lineage.

"Mind make human difference from animal"

 
And Allâh has brought you out from the wombs of your mothers while you know nothing. And He gave you hearing, sight, and hearts( minds)  that you might give thanks (to Allâh). (al-Nahl , 16:78)


 “Dan Allah mengeluarkan kamu dari perut ibu kamu dengan keadaan tidak mengetahui sesuatu pun; dan Ia mengurniakan kepada kamu pendengaran dan penglihatan serta hati (akal fikiran); supaya kamu bersyukur.” (Surah al-Nahl, ayat 78)


From the surah above, is very clear that Allah give us minds or inteligence besides hearing and sight for us. Minds make us very different from any intelligence creatures in the planet of the earth. From the post of story about 3 alien is clear that human very distinguish from another because of their intelligence.


Scientist not fully understanding what the relationship of genetic with minds ability, perhaps not all about genetic. May be something else. Wallahualam.(only Allah Know). let us pray to Allah to borrow His knowledge to us in understanding genetic.

The heart disease: the genes responsible still elusive


The researcher try one approach in understanding disease by find what are genes are responsible in the particular disease (the common genes express in patients). The type of study begin 5 year ago when a study of 146 Caucasian volunteers turned up a common gene variant among those with the eye disease macular degeneration.
Researchers had used a new strategy: They scanned large stretches of the genomes of the sick and the healthy and found a single DNA base that was much more likely to be present in those whose eyes were failing.
The finding was remarkable: Relatively few people participated in the study, yet those with two copies of the suspect gene variant had 10 times the risk of macular degeneration, a huge increase. Furthermore, the method the group used, called genome-wide association (GWA), had some big advantages: It was unbiased, testing thousands of gene-disease associations at once, not just a researcher’s favorites. And it pointed to common variants, found in at least 5% of individuals studied. GWA studies offered hope of identifying people at risk for diseases, uncovering new disease mechanisms, and finding new targets for therapy.
The researcher also used the GWA studies in the heart disease. But the results are not like expexced. “People did studies with 300 or 500 people and didn’t find anything, then did 1000 and didn’t find anything,” says Deepak Srivastava, who directs the Gladstone Institute of Cardiovascular Disease at the University of California (UC), San Francisco. It quickly became clear that macular degeneration was an exception.
The results from one group of GWA studies, for heart disease, are typical, with a mixed record and an uncertain legacy. The technique has identified dozens of variants, but all have weak effects; so far, almost none has led to DNA changes that actually cause disease. Researchers have had more success finding variants that link to tightly defined conditions like high cholesterol than to heart failure, a catch-all disease.
For me I suggest that the GWA studies must be more specific to what causes of heart disease so may be we can know what genes cause particular heart disease.

The story about 3 alien? (what make us human version 1.50)




Not too long ago three aliens descended to Earth to evaluate the status of intelligent life. One specialized in engineering, one in chemistry and one in computation. Turning to his colleagues, the engineer reported (translation follows): “All of the creatures here are solid, some segmented, with capacities to move on the
ground, through the water or air. All extremely slow. Unimpressive.” The chemist then commented: “All quite similar, derived from different sequences of four chemical ingredients.” Next the computational
expert opined: “Limited computing abilities. But one, the hairless biped, is unlike the others. It exchanges information in a manner that is primitive and inefficient but remarkably different from the others. It creates many odd objects, including ones that are consumable, others that produce symbols, and yet others that destroy members of its tribe.”


“But how can this be?” the engineer mused. “Given the similarity in form and chemistry, how can their computing capacity differ?” “I am not certain,” confessed the computational alien. “But they appear to have  a system for creating new expressions that is infinitely more powerful than those of all the other living kinds. I propose that we place the hairless biped in a different group from the other animals, with a separate origin, and from a different galaxy.” The other two aliens nodded, and then all three zipped home to present their report.


What so special about human? Again, because of our brain. From the post "what make us human", the 1% or 2% difference, they differ genes in brain developments. But scientist not fully understanding the role of genes differences in human can give significantly give the brain has ability that only human race have. The gene encoded for protein no longer the answer, may be non coding DNA, perhaps RNAs.

In Islamic perspectives, Human are the very special creatures that create as Khalif (leader) and the give the very special "nikmat" which is the intelligence. In Al-quran, always repeat this phrases أفلا تعقلون reads "Affala Ta'kiluun" which means Don't you think?. So Islam teach people always to use their intelligence.

 Key ingredient of human mind

 The four traits below distinguish the human mind from those ofanimals. Uncovering the origin of the human mind will require explaining how these unique properties came about.

Generative computation enables humans to create a virtually limitless variety of words, concepts and things. The characteristic encompasses two types of operation: recursive and combinatorial. Recursion is the repeated use of a rule to create new expressions. The combinatorial operation is the mixing of discrete elements to engender new ideas.

Promiscuous combination of ideas allows the mingling of different domains of knowledge—such as art, sex, space, causality and friendship—thereby generating new laws, social relationships and technologies. Mental symbols encode sensory experiences both real and imagined, forming the basis of a rich and complex system of communication. Such symbols can be kept to oneself or expressed to others as words or pictures.

Abstract thought permits contemplation of things beyond what we can see, hear, touch, taste or smell.

Hobbit from Indonesia- human evolution need revision




In 2004 a team of Australian and Indonesian scientists who had been excavating a cave called Liang Bua on the Indonesian island of Flores announced that they had unearthed something extraordinary: a partial skeleton of an adult human female who would have stood just over a meter tall and who had a brain a third as large as our own. The specimen, known to scientists as LB1, quickly received a fanciful nickname—the hobbit,like a race in Lord of the Ring. The team proposed that LB1 and the other fragmentary remains they recovered represent a previously unknown human species, Homo floresiensis. Their best guess was that H. floresiensis was a descendant of H. erectus—the first species known to have colonized outside of Africa. The creature evolved its small size, they surmised, as a response to the limited resources available on its island home—a phenomenon that had previously been documented in other mammals, but never humans.


Scientists initially postulated that H. floresiensis descended from H. erectus, a human ancestor with body proportions similar to our own.New investigations show that the hobbits were more primitive than researchers thought, however—a finding that could overturn key assumptions about human evolution.